Diagnostic Accuracy of Cartilage Oligomeric Matrix Protein (COMP), for Cartilage Damage in Rheumatoid Arthritis
نویسندگان
چکیده
منابع مشابه
Cartilage Oligomeric Matrix Protein (COMP): A Biomarker of Arthritis
Arthritis is a chronic disease with a significant impact on the population. It damages the cartilage, synovium, and bone of the joints causing pain, impairment, and disability in patients. Current methods for diagnosis of and monitoring the disease are only able to detect clinical manifestations of arthritis late in the process. However, with the recent onset of successful treatments for rheuma...
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Changes in serum cartilage oligomeric matrix protein (COMP) were studied during a 6-month period from initiation of treatment of rheumatoid arthritis patients with either infliximab or etanercept, to elucidate whether the favourable results of tissue protection reported in clinical trials are corroborated by changing levels of circulating COMP. Rheumatoid arthritis patients commencing treatment...
متن کاملRelationship between cartilage oligomeric matrix protein (COMP) and rheumatoid arthritis severity
Background Serum cartilage oligomeric matrix protein (COMP) is a non-collagen glycoprotein produced by the cartilage, synovium, tendon, and meniscus. Recent studies showed that COMP is a reliable factor for monitoring cartilage damage. Objective To determine the relationship between serum COMP concentration and the severity of rheumatoid arthritis (RA). Methods This cross-sectional study la...
متن کاملRole of Serum cartilage oligomeric matrix protein (COMP) in the diagnosis of rheumatoid arthritis (RA): A case–control study
OBJECTIVE To analyse the role of serum cartilage oligomeric matrix protein (COMP) levels in the differential diagnosis of rheumatoid arthritis (RA). METHODS This case-control study analysed the clinical and laboratory characteristics of patients with RA and healthy control subjects. The diagnostic ability of COMP for RA was evaluated by comparing it with anti-cyclic citrullinated peptide anti...
متن کاملCartilage Oligomeric Matrix Protein (COMP) and Hyaluronic Acid (HA): Diagnostic Biomarkers of Knee Osteoarthritis
Osteoarthritis (OA), leads to considerable morbidity and disability in elderly [1]. The condition is diagnosed basically on clinical presentation and radiographic findings. By the time changes are visible on radiographs the disease is fairly advanced. Radiographic changes are apparent only after a year or two, but changes in biomarker levels are apparent within a few months [2]. Biomarkers are ...
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ژورنال
عنوان ژورنال: Journal of Advances in Medicine and Medical Research
سال: 2020
ISSN: 2456-8899
DOI: 10.9734/jammr/2020/v32i1630631